Complexation with organometallic ruthenium pharmacophores enhances the ability of 4-anilinoquinazolines inducing apoptosis

Wei Zheng; Qun Luo; Yu Lin; Yao Zhao; Xiuli Wang; Zhifeng Du; Xiang Hao; Yang Yu; Shuang Lü; Liyun Ji; Xianchan Li; Ling Yang; Fuyi Wang

doi:10.1039/C3CC43000F

Complexation with organometallic ruthenium pharmacophores enhances the ability of 4-anilinoquinazolines inducing apoptosis†

Wei Zheng,^ab Qun Luo,^ab Yu Lin,^ab Yao Zhao,^ab Xiuli Wang,^c Zhifeng Du,^ab Xiang Hao,^a Yang Yu,^c Shuang Lü,^ab Liyun Ji,^ab Xianchan Li,^ab Ling Yang^c and Fuyi Wang*^ab

Author affiliations

* Corresponding authors

^a Beijing National Laboratory for Molecular Sciences, Beijing 100190, PR China

^b CAS Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China
E-mail: fuyi.wang@iccas.ac.cn
Fax: +86-10-6252-9069

^c Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, PR China

Abstract

The complexation with organoruthenium fragments confers 4-anilinoquinazoline pharmacophores with higher potential for inducing cellular apoptosis while the highly inhibitory activity of 4-anilinoquinazolines against EGFR and the reactivity of the ruthenium centre to 9-ethylguanine are well preserved.

Chemical Communications

Complexation with organometallic ruthenium pharmacophores enhances the ability of 4-anilinoquinazolines inducing apoptosis†

Abstract

Supplementary files

Additions and corrections

Article information

Download Citation

Permissions

Complexation with organometallic ruthenium pharmacophores enhances the ability of 4-anilinoquinazolines inducing apoptosis

Social activity

Search articles by author

Spotlight

Advertisements