Issue 80, 2013
From the journal:

Chemical Communications

A bisphosphonate tweezers and clickable PEGylated PAMAM dendrons for the preparation of functional iron oxide nanoparticles displaying renal and hepatobiliary elimination†

Cynthia Ghobril,‡a   Gabriela Popa,‡a   Audrey Parat,a   Claire Billotey,*b   Jacqueline Taleb,c   Pauline Bonazza,c   Sylvie Begin-Colin*a  and  Delphine Felder-Flesch*a  

* Corresponding authors

a IPCMS, UMR CNRS-UdS-ECPM 7504 23 rue du loess BP 43, 67034 Strasbourg, France
E-mail: Sylvie.Begin@ipcms.u-strasbg.fr, Delphine.Felder@ipcms.u-strasbg.fr
Fax: +33 388 10 72 46
Tel: +33 388 10 71 63

b Université Claude Bernard Lyon 1, Laboratoire LPCML, UMR5620 CNRS, Domaine Scientifique de La Doua, Batiment Kastler, 10 rue Ada Byron, 69622 Villeurbanne Cedex, France
E-mail: claire.billotey@orange.fr
Fax: +33 472 11 69 57
Tel: +33 472 68 46 17

c Hospices Civils de Lyon, Service de Médecine Nucléaire, Hôpital Edouard Herriot, 5 place d'Arsonval, 69437 Lyon cedex 03, France

Abstract

The functionalization of superparamagnetic iron oxide nanoparticles (SPION) with PEGylated PAMAM dendrons through a bisphosphonate tweezers yielded 15 and 30 nm dendritic nano-objects stable in physiological media and showing both renal and hepatobiliary elimination.

Graphical abstract: A bisphosphonate tweezers and clickable PEGylated PAMAM dendrons for the preparation of functional iron oxide nanoparticles displaying renal and hepatobiliary elimination

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Article information

DOI
https://doi.org/10.1039/C3CC43161D
Article type
Communication
Submitted
29 Apr 2013
Accepted
08 Aug 2013
First published
08 Aug 2013

Chem. Commun., 2013,49, 9158-9160

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A bisphosphonate tweezers and clickable PEGylated PAMAM dendrons for the preparation of functional iron oxide nanoparticles displaying renal and hepatobiliary elimination

C. Ghobril, G. Popa, A. Parat, C. Billotey, J. Taleb, P. Bonazza, S. Begin-Colin and D. Felder-Flesch, Chem. Commun., 2013, 49, 9158 DOI: 10.1039/C3CC43161D

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