Issue 61, 2013
From the journal:

Chemical Communications

Hybridization chain reaction-based branched rolling circle amplification for chemiluminescence detection of DNA methylation†

Sai Bi,ab   Tingting Zhao,b   Baoyu Luob  and  Jun-Jie Zhu*a  

* Corresponding authors

a State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China
E-mail: jjzhu@nju.edu.cn
Fax: +86-25-83597204
Tel: +86-25-83597204

b Key Laboratory of Sensor Analysis of Tumor Marker, Ministry of Education, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China

Abstract

A novel hybridization chain reaction-based branched rolling circle amplification combining the fabrication of multi-HRP-capped MNPs is developed for chemiluminescence detection of DNA methyltransferase activities and inhibitors with high sensitivity in a well-controlled manner.

Graphical abstract: Hybridization chain reaction-based branched rolling circle amplification for chemiluminescence detection of DNA methylation

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Article information

DOI
https://doi.org/10.1039/C3CC43353F
Article type
Communication
Submitted
06 May 2013
Accepted
12 Jun 2013
First published
12 Jun 2013

Chem. Commun., 2013,49, 6906-6908

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Hybridization chain reaction-based branched rolling circle amplification for chemiluminescence detection of DNA methylation

S. Bi, T. Zhao, B. Luo and J. Zhu, Chem. Commun., 2013, 49, 6906 DOI: 10.1039/C3CC43353F

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