Issue 64, 2013
From the journal:

Chemical Communications

Glycan arrays containing synthetic Clostridium difficilelipoteichoic acid oligomers as tools toward a carbohydrate vaccine†

Christopher E. Martin,ab   Felix Broecker,ab   Steffen Eller,a   Matthias A. Oberli,‡a   Chakkumkal Anish,a   Claney L. Pereira*a  and  Peter H. Seeberger*ab  

* Corresponding authors

a Max Planck Institute of Colloids and Interfaces, 14424 Potsdam, Germany
E-mail: ClaneyLebev.Pereira@mpikg.mpg.de, Peter.Seeberger@mpikg.mpg.de

b Freie Universität Berlin, 14195 Berlin, Germany

Abstract

Clostridium difficile is a leading cause of severe nosocomial infections. Cell-surface carbohydrate antigens are promising vaccine candidates. Here we report the first total synthesis of oligomers of the lipoteichoic acid antigen repeating unit. Synthetic glycan microarrays revealed anti-glycan antibodies in the blood of patients that help to define epitopes for vaccine development.

Graphical abstract: Glycan arrays containing synthetic Clostridium difficile lipoteichoic acid oligomers as tools toward a carbohydrate vaccine

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Article information

DOI
https://doi.org/10.1039/C3CC43545H
Article type
Communication
Submitted
12 May 2013
Accepted
17 Jun 2013
First published
18 Jun 2013

Chem. Commun., 2013,49, 7159-7161

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Glycan arrays containing synthetic Clostridium difficile lipoteichoic acid oligomers as tools toward a carbohydrate vaccine

C. E. Martin, F. Broecker, S. Eller, M. A. Oberli, C. Anish, C. L. Pereira and P. H. Seeberger, Chem. Commun., 2013, 49, 7159 DOI: 10.1039/C3CC43545H

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