Issue 82, 2013
From the journal:

Chemical Communications

Polymers with tunable side-chain amphiphilicity as non-hemolytic antibacterial agents†

Divakara S. S. M. Uppu,a   Padma Akkapeddi,a   Goutham B. Manjunath,a   Venkateswarlu Yarlagadda,a   Jiaul Hoquea  and  Jayanta Haldar*a  

* Corresponding authors

a Bioorganic and Medicinal Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bengaluru, India
E-mail: jayanta@jncasr.ac.in
Fax: +91-80-2208-2627
Tel: +91-80-2208-2565

Abstract

Quaternized polymers mimicking the antimicrobial peptides were created by tuning the side-chain amphiphilicity using a first-time approach of post-functionalization. They displayed excellent efficacy against pathogenic bacteria even in human plasma and membrane disruptive mode of action. The optimized polymers and degraded products were non-hemolytic.

Graphical abstract: Polymers with tunable side-chain amphiphilicity as non-hemolytic antibacterial agents

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Article information

DOI
https://doi.org/10.1039/C3CC43751E
Article type
Communication
Submitted
18 May 2013
Accepted
28 Jun 2013
First published
28 Jun 2013

Chem. Commun., 2013,49, 9389-9391

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Polymers with tunable side-chain amphiphilicity as non-hemolytic antibacterial agents

D. S. S. M. Uppu, P. Akkapeddi, G. B. Manjunath, V. Yarlagadda, J. Hoque and J. Haldar, Chem. Commun., 2013, 49, 9389 DOI: 10.1039/C3CC43751E

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