Issue 67, 2013

2′,4′-BNA bearing a chiral guanidinopyrrolidine-containing nucleobase with potent ability to recognize the CG base pair in a parallel-motif DNA triplex

Abstract

In order to expand the target sequence used in triplex DNA formation, seven novel nucleotide analogues were synthesized and incorporated into triplex-forming oligonucleotides by post-elongation modification approaches. Among them, GPB, equipped with a suitable restricted conformation of sugar and nucleobase moieties, was found to have the highest sequence-selectivity and affinity towards CG base pairs within double-stranded DNA.

Graphical abstract: 2′,4′-BNA bearing a chiral guanidinopyrrolidine-containing nucleobase with potent ability to recognize the CG base pair in a parallel-motif DNA triplex

Supplementary files

Article information

Article type
Communication
Submitted
29 May 2013
Accepted
25 Jun 2013
First published
25 Jun 2013

Chem. Commun., 2013,49, 7421-7423

2′,4′-BNA bearing a chiral guanidinopyrrolidine-containing nucleobase with potent ability to recognize the CG base pair in a parallel-motif DNA triplex

Y. Hari, M. Akabane and S. Obika, Chem. Commun., 2013, 49, 7421 DOI: 10.1039/C3CC44030C

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