Issue 72, 2013
From the journal:

Chemical Communications

The G-triplex DNA could function as a new variety of DNA peroxidase†

Shaoru Wang,‡a   Boshi Fu,‡a   Shuang Peng,a   Xiaoe Zhang,a   Tian Tian*a  and  Xiang Zhou*ab  

* Corresponding authors

a College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, State Key Laboratory of Virology, Wuhan University, Wuhan, Hubei, P. R. China
E-mail: xzhou@whu.edu.cn, ttian@whu.edu.cn
Fax: +86-27-68756663
Tel: +86-27-68756663

b State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China

Abstract

This study is the first to investigate the interactions of hemin with a G-triplex DNA of T1 using different DNA binding assays. The low intrinsic peroxidatic activity of hemin could be significantly enhanced using T1. Furthermore, much decreased oxidation enhancement by T2 or T3 with one key guanine mutation was observed, and the observed peroxidatic activity of T1 should be directly due to the G-triplex complexed with hemin.

Graphical abstract: The G-triplex DNA could function as a new variety of DNA peroxidase

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C3CC44075C
Article type
Communication
Submitted
30 May 2013
Accepted
25 Jun 2013
First published
26 Jun 2013

Chem. Commun., 2013,49, 7920-7922

Permissions

Request permissions

The G-triplex DNA could function as a new variety of DNA peroxidase

S. Wang, B. Fu, S. Peng, X. Zhang, T. Tian and X. Zhou, Chem. Commun., 2013, 49, 7920 DOI: 10.1039/C3CC44075C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements