Issue 72, 2013
From the journal:

Chemical Communications

IBX mediated reaction of β-enamino esters with allylic alcohols: a one pot metal free domino approach to functionalized pyridines†

Narendar Reddy Gade,a   V. Devendram,a   Manojit Pal*a  and  Javed Iqbal*a  

* Corresponding authors

a Dr Reddy's Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, India
E-mail: manojitpal@rediffmail.com, jiqbal@ilsresearch.org
Tel: +91 40 6657 1500

Abstract

IBX facilitated the reaction of β-enamino esters with allylic alcohols affording a direct, one-pot and metal free synthesis of functionalized pyridines including 2-substituted nicotinic acids, densely substituted pyridines and precursors of azafluorenones. The methodology also afforded the racemic pyridine core of cyclothiazomycin.

Graphical abstract: IBX mediated reaction of β-enamino esters with allylic alcohols: a one pot metal free domino approach to functionalized pyridines

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Article information

DOI
https://doi.org/10.1039/C3CC44274H
Article type
Communication
Submitted
06 Jun 2013
Accepted
09 Jul 2013
First published
09 Jul 2013

Chem. Commun., 2013,49, 7926-7928

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IBX mediated reaction of β-enamino esters with allylic alcohols: a one pot metal free domino approach to functionalized pyridines

N. R. Gade, V. Devendram, M. Pal and J. Iqbal, Chem. Commun., 2013, 49, 7926 DOI: 10.1039/C3CC44274H

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