Issue 70, 2013
From the journal:

Chemical Communications

The iron-catalyzed construction of 2-aminopyrimidines from alkynenitriles and cyanamides†

Timothy K. Lane,a   Minh H. Nguyen,a   Brendan R. D'Souza,a   Nathan A. Spahna  and  Janis Louie*a  

* Corresponding authors

a The University of Utah, 315 S. 1400 E. RM. 2020, Salt Lake City, UT 84102, USA
E-mail: louie@chem.utah.edu
Fax: +1 801-581-8433
Tel: +1 801-581-6681

Abstract

Several cycloaddition catalysts and reagents were surveyed for their effectiveness toward cyclizing alkynenitriles with cyanamides. Catalytic amounts of FeI2, iPrPDAI and Zn were found to effectively catalyze the [2+2+2] cycloaddition of a variety of cyanamides and alkynenitriles to afford bicyclic 2-aminopyrimidines.

Graphical abstract: The iron-catalyzed construction of 2-aminopyrimidines from alkynenitriles and cyanamides

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Article information

DOI
https://doi.org/10.1039/C3CC44422H
Article type
Communication
Submitted
12 Jun 2013
Accepted
12 Jul 2013
First published
16 Jul 2013

Chem. Commun., 2013,49, 7735-7737

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The iron-catalyzed construction of 2-aminopyrimidines from alkynenitriles and cyanamides

T. K. Lane, M. H. Nguyen, B. R. D'Souza, N. A. Spahn and J. Louie, Chem. Commun., 2013, 49, 7735 DOI: 10.1039/C3CC44422H

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