Issue 67, 2013
From the journal:

Chemical Communications

A nanocarrier based on a genetically engineered protein cage to deliver doxorubicin to human hepatocellular carcinoma cells†

Riki Toita,‡ab   Masaharu Murata,*acd   Kana Abe,d   Sayoko Narahara,ac   Jing Shu Piao,a   Jeong-Hun Kangb  and  Makoto Hashizumeacd  

* Corresponding authors

a Department of Advanced Medical Initiatives, Faculty of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
E-mail: m-murata@dem.med.kyushu-u.ac.jp
Fax: +81-92-642-6252
Tel: +81-92-642-6251

b Department of Biomedical Engineering, National Cerebral and Cardiovascular Center Research Institutes, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan

c Innovation Center for Medical Redox Navigation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan

d Center for Advanced Medical Innovation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan

Abstract

Herein, we report the preparation of genetically engineered protein cages (HspG41C-SP94), taken up selectively by human hepatocellular carcinoma (HCC) cells. An engineered protein cage–doxorubicin (DOX) conjugate was as cytotoxic as free DOX against HCC cells but much less cytotoxic against normal hepatocytes.

Graphical abstract: A nanocarrier based on a genetically engineered protein cage to deliver doxorubicin to human hepatocellular carcinoma cells

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Article information

DOI
https://doi.org/10.1039/C3CC44508A
Article type
Communication
Submitted
16 Jun 2013
Accepted
26 Jun 2013
First published
27 Jun 2013

Chem. Commun., 2013,49, 7442-7444

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A nanocarrier based on a genetically engineered protein cage to deliver doxorubicin to human hepatocellular carcinoma cells

R. Toita, M. Murata, K. Abe, S. Narahara, J. S. Piao, J. Kang and M. Hashizume, Chem. Commun., 2013, 49, 7442 DOI: 10.1039/C3CC44508A

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