Issue 83, 2013
From the journal:

Chemical Communications

A chemical genomics approach to identification of interactions between bioactive molecules and alternative reading frame proteins†

Paul C. Taylor,*a   Andrew J. Clark,a   Andrew Marsh,a   Donald R. J. Singerb  and  Suzanne J. Dillyc  

* Corresponding authors

a Department of Chemistry, University of Warwick, Coventry, UK
E-mail: p.c.taylor@warwick.ac.uk
Fax: +44 (0)24 76524112
Tel: +44 (0)24 76524375

b Warwick Medical School, University of Warwick and University Hospital, Coventry, UK

c SEEK, CentralPoint, 45 Beech Street, London, UK

Abstract

Magic Tag® immobilisation of bioactive molecules coupled with bacteriophage display, followed by an ELISA assay, provides a protocol that can probe interactions of drugs with putative products of alternative initiation of translation as exemplified by the binding of immobilised flecainide to protein products of genes linked to sudden cardiac death.

Graphical abstract: A chemical genomics approach to identification of interactions between bioactive molecules and alternative reading frame proteins

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Article information

DOI
https://doi.org/10.1039/C3CC44647F
Article type
Communication
Submitted
20 Jun 2013
Accepted
30 Aug 2013
First published
02 Sep 2013

Chem. Commun., 2013,49, 9588-9590

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A chemical genomics approach to identification of interactions between bioactive molecules and alternative reading frame proteins

P. C. Taylor, A. J. Clark, A. Marsh, D. R. J. Singer and S. J. Dilly, Chem. Commun., 2013, 49, 9588 DOI: 10.1039/C3CC44647F

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