Issue 70, 2013

Novel preparation of chiral α-amino acids using the Mitsunobu–Tsunoda reaction

Abstract

An efficient synthesis of racemic or optically active α-amino acids by modified-Mitsunobu alkylation of a racemic or chiral glycine template from alcohols was developed. Libraries of amino acids were prepared in moderate to good yield with good to high enantioselectivity. This simple method widens the scope for preparation of structurally diverse amino acids.

Graphical abstract: Novel preparation of chiral α-amino acids using the Mitsunobu–Tsunoda reaction

Supplementary files

Article information

Article type
Communication
Submitted
23 Jun 2013
Accepted
10 Jul 2013
First published
12 Jul 2013

Chem. Commun., 2013,49, 7744-7746

Novel preparation of chiral α-amino acids using the Mitsunobu–Tsunoda reaction

A. F. M. Noisier, C. S. Harris and M. A. Brimble, Chem. Commun., 2013, 49, 7744 DOI: 10.1039/C3CC44717K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements