Issue 83, 2013
From the journal:

Chemical Communications

Increased ion conductance across mammalian membranes modified with conjugated oligoelectrolytes†

Jenny Du,a   Alexander W. Thomas,a   Xiaofen Chen,a   Logan E. Garner,a   Carol A. Vandenbergbc  and  Guillermo C. Bazan*ad  

* Corresponding authors

a Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA, USA

b Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA, USA

c Neuroscience Research Institute, University of California, Santa Barbara, CA, USA

d Department of Materials, University of California, Santa Barbara, CA, USA
E-mail: bazan@chem.ucsb.edu

Abstract

Variation in conjugated oligoelectrolyte (COE) repeat units is shown to affect the rate of COE insertion into mammalian membrane patches and membrane patch stabilities. These findings suggest that it is possible to find COE structures that do not destroy membranes while at the same time allow for more facile transmembrane movement of ions/substrates.

Graphical abstract: Increased ion conductance across mammalian membranes modified with conjugated oligoelectrolytes

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Article information

DOI
https://doi.org/10.1039/C3CC45094E
Article type
Communication
Submitted
07 Jul 2013
Accepted
02 Sep 2013
First published
02 Sep 2013

Chem. Commun., 2013,49, 9624-9626

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Increased ion conductance across mammalian membranes modified with conjugated oligoelectrolytes

J. Du, A. W. Thomas, X. Chen, L. E. Garner, C. A. Vandenberg and G. C. Bazan, Chem. Commun., 2013, 49, 9624 DOI: 10.1039/C3CC45094E

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