Issue 83, 2013

Asymmetric formation of tert-alkylamines from serinols by a dual function catalyst

Abstract

Consecutive intramolecular desymmetrization and kinetic resolution of 2-substituted N-phenoxycarbonylserinols have been achieved in one-pot by a single chiral catalyst, bisox(7)–CuCl2, to form oxazolidinones with remarkable enantioselectivities (94–99% ee) as tert-alkylamine building blocks. The process culminates in a dual-function of the chiral catalyst.

Graphical abstract: Asymmetric formation of tert-alkylamines from serinols by a dual function catalyst

Supplementary files

Article information

Article type
Communication
Submitted
07 Jul 2013
Accepted
22 Aug 2013
First published
10 Sep 2013

Chem. Commun., 2013,49, 9669-9671

Asymmetric formation of tert-alkylamines from serinols by a dual function catalyst

Y. S. You, T. W. Kim and S. H. Kang, Chem. Commun., 2013, 49, 9669 DOI: 10.1039/C3CC45099F

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