Issue 85, 2013
From the journal:

Chemical Communications

Metallo-toeholds: controlling DNA strand displacement driven by Hg(ii) ions†

Wei Ding,a   Wei Deng,a   Hong Zhua  and  Haojun Liang*ab  

* Corresponding authors

a CAS Key Laboratory of Soft Matter Chemistry, Collaborative Innovation Center of Chemistry for Energy Materials, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China
E-mail: hjliang@ustc.edu.cn
Fax: +86-551-63607824
Tel: +86-551-63607824

b Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China

Abstract

Toehold-mediated strand displacement is a powerful tool that permits programmable control over DNA hybridization. Here, we developed a mechanism for strand displacement driven by Hg2+ ions, in which the insertion of thymine–thymine mismatched base pairs on the toeholds provides additional control through variation of the concentration of Hg2+ ions.

Graphical abstract: Metallo-toeholds: controlling DNA strand displacement driven by Hg(ii) ions

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Article information

DOI
https://doi.org/10.1039/C3CC45373A
Article type
Communication
Submitted
16 Jul 2013
Accepted
27 Aug 2013
First published
28 Aug 2013

Chem. Commun., 2013,49, 9953-9955

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Metallo-toeholds: controlling DNA strand displacement driven by Hg(II) ions

W. Ding, W. Deng, H. Zhu and H. Liang, Chem. Commun., 2013, 49, 9953 DOI: 10.1039/C3CC45373A

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