Stabilized Wittig olefination holds great potential as a bioconjugation reaction. We demonstrate that the reaction of stabilized phosphorus ylides (or phosphonium salts) with aryl aldehydes is sufficiently robust to be used for live cell affinity isolation and fluorescence tagging of a protein, FKBP12.
K. M. Lum, V. J. Xavier, M. J.-H. Ong, C. W. Johannes and K. Chan, Chem. Commun., 2013, 49, 11188 DOI: 10.1039/C3CC45961F
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