Issue 87, 2013
From the journal:

Chemical Communications

Coupling reaction of thioamides with sulfonyl azides: an efficient catalyst-free click-type ligation under mild conditions†

Muhammad Aswad,a   Junya Chiba,*a   Takenori Tomohiroa  and  Yasumaru Hatanaka*a  

* Corresponding authors

a Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan
E-mail: chiba@pha.u-toyama.ac.jp, yasu@pha.u-toyama.ac.jp

Abstract

We report a coupling reaction of thioamides and sulfonyl azides to generate sulfonyl amidines in the absence of any activation additives. The reaction progresses in various solvents under mild conditions. Water exhibits the highest performance with respect to efficiency.

Graphical abstract: Coupling reaction of thioamides with sulfonyl azides: an efficient catalyst-free click-type ligation under mild conditions

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Article information

DOI
https://doi.org/10.1039/C3CC46055J
Article type
Communication
Submitted
08 Aug 2013
Accepted
10 Sep 2013
First published
10 Sep 2013

Chem. Commun., 2013,49, 10242-10244

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Coupling reaction of thioamides with sulfonyl azides: an efficient catalyst-free click-type ligation under mild conditions

M. Aswad, J. Chiba, T. Tomohiro and Y. Hatanaka, Chem. Commun., 2013, 49, 10242 DOI: 10.1039/C3CC46055J

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