Issue 91, 2013
From the journal:

Chemical Communications

One-pot, single-step deracemization of 2-hydroxyacids by tandem biocatalytic oxidation and reduction†

Ya-Ping Xue,ab   Yu-Guo Zheng,*ab   Ya-Qin Zhang,ab   Jing-Lei Sun,ab   Zhi-Qiang Liuab  and  Yin-Chu Shenab  

* Corresponding authors

a Institute of Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China
E-mail: zhengyg@zjut.edu.cn
Fax: +86-571-88320630
Tel: +86-571-88320630

b Engineering Research Center of Bioconversion and Biopurification of Ministry of Education, Zhejiang University of Technology, Hangzhou 310014, China

Abstract

A facile and efficient one-pot, single-step method for deracemizing a broad range of 2-hydroxyacids to (R)-2-hydroxyacids was established by combination of resting cells of an (S)-hydroxyacid dehydrogenase-producing microorganism and an (R)-ketoacid reductase-producing microorganism.

Graphical abstract: One-pot, single-step deracemization of 2-hydroxyacids by tandem biocatalytic oxidation and reduction

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Article information

DOI
https://doi.org/10.1039/C3CC46240D
Article type
Communication
Submitted
15 Aug 2013
Accepted
23 Sep 2013
First published
24 Sep 2013

Chem. Commun., 2013,49, 10706-10708

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One-pot, single-step deracemization of 2-hydroxyacids by tandem biocatalytic oxidation and reduction

Y. Xue, Y. Zheng, Y. Zhang, J. Sun, Z. Liu and Y. Shen, Chem. Commun., 2013, 49, 10706 DOI: 10.1039/C3CC46240D

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