Cascade fluorofunctionalisation of 2,3-unsubstituted indoles featuring the formation of C–C, C–F and C–O bonds via electrophilic fluorination using N-fluorobenzenesulfonimide is described. The use of an O-nucleophile tethered to the nitrogen of indoles enables the synthesis of polycyclic fluorinated indoline derivatives from simple precursors in 40–63% yields.
T. M. Nguyen, H. A. Duong, J. Richard, C. W. Johannes, F. Pincheng, D. Kwong Jia Ye and E. L. Shuying, Chem. Commun., 2013, 49, 10602 DOI: 10.1039/C3CC46564K
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