Facile synthesis of trifluoroethyl compounds by the Suzuki cross-coupling reactions of CF3CH2OTs with arylboronic acids

Faqiang Leng; Yaping Wang; Hui Li; Jingya Li; Dapeng Zou; Yangjie Wu; Yusheng Wu

doi:10.1039/C3CC46601A

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Facile synthesis of trifluoroethyl compounds by the Suzuki cross-coupling reactions of CF₃CH₂OTs with arylboronic acids†

Faqiang Leng,^a Yaping Wang,^a Hui Li,^a Jingya Li,^b Dapeng Zou,*^ab Yangjie Wu^a and Yusheng Wu*^bc

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* Corresponding authors

^a The College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, P. R. China
E-mail: zdp@zzu.edu.cn
Fax: +86 371 6776 3390
Tel: +86 371 6776 6865

^b Tetranov Biopharm, LLC, No. 75 Daxue Road, Zhengzhou, P. R. China

^c Tetranov International, Inc., 100 Jersey Avenue, Suite A340, New Brunswick, NJ 08901, USA
E-mail: yusheng.wu@tetranovglobal.com
Fax: +1 732 253 7327
Tel: +1 732 253 7326

Abstract

This research provides a novel approach for introducing a CF₃CH₂ group onto aromatic rings using Pd(OAc)₂/palladacycle as a catalyst for the Suzuki cross-coupling reaction of CF₃CH₂OTs (OTs = 4-methylbenzene sulfonate) with arylboronic acids.

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Article information

DOI: https://doi.org/10.1039/C3CC46601A
Article type: Communication
Submitted: 28 Aug 2013
Accepted: 26 Sep 2013
First published: 27 Sep 2013

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Chem. Commun., 2013,49, 10697-10699

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Facile synthesis of trifluoroethyl compounds by the Suzuki cross-coupling reactions of CF₃CH₂OTs with arylboronic acids

F. Leng, Y. Wang, H. Li, J. Li, D. Zou, Y. Wu and Y. Wu, Chem. Commun., 2013, 49, 10697 DOI: 10.1039/C3CC46601A

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Chemical Communications