In vitro and in vivo imaging application of a 1,8-naphthalimide-derived Zn2+ fluorescent sensor with nuclear envelope penetrability

Changli Zhang; Zhipeng Liu; Yunling Li; Weijiang He; Xiang Gao; Zijian Guo

doi:10.1039/C3CC46862C

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In vitro and in vivo imaging application of a 1,8-naphthalimide-derived Zn²⁺ fluorescent sensor with nuclear envelope penetrability†

Changli Zhang,^ab Zhipeng Liu,^c Yunling Li,^a Weijiang He,*^a Xiang Gao^d and Zijian Guo*^a

Author affiliations

* Corresponding authors

^a State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China
E-mail: heweij69@nju.edu.cn, zguo@nju.edu.cn
Fax: +86 25 83314502
Tel: +86 25 83597066

^b Department of Chemistry, Nanjing Xiaozhuang College, Nanjing 210017, P. R. China

^c Department of Chemistry, Liaocheng University, Liaocheng 252059, P. R. China

^d Animal Model Research Center, Nanjing University, Nanjing 210061, P. R. China

Abstract

A newly developed fluorescent sensor, Naph-BPEA, shows a specific turn-on response to Zn²⁺ and can be excited by visible light. The in situ nuclear Zn²⁺ imaging in HeLa and HepG2 cells reveals the nuclear envelope penetrability of the sensor. The specific sensor location in a zebrafish larva was also demonstrated.

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Article information

DOI: https://doi.org/10.1039/C3CC46862C
Article type: Communication
Submitted: 07 Sep 2013
Accepted: 14 Oct 2013
First published: 15 Oct 2013

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Chem. Commun., 2013,49, 11430-11432

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In vitro and in vivo imaging application of a 1,8-naphthalimide-derived Zn²⁺ fluorescent sensor with nuclear envelope penetrability

C. Zhang, Z. Liu, Y. Li, W. He, X. Gao and Z. Guo, Chem. Commun., 2013, 49, 11430 DOI: 10.1039/C3CC46862C

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Chemical Communications