Issue 100, 2013
From the journal:

Chemical Communications

One pot synthesis of bioactive benzopyranones through palladium-catalyzed C–H activation and CO insertion into 2-arylphenols†

Tai-Hua Lee,a   Jayachandran Jayakumar,b   Chien-Hong Cheng*b  and  Shih-Ching Chuang*a  

* Corresponding authors

a Department of Applied Chemistry, National Chiao Tung University, Hsinchu 30010, Taiwan, R.O.C.
E-mail: jscchuang@faculty.nctu.edu.tw
Fax: +886-35723764
Tel: +886-35731858

b Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan, R.O.C.
E-mail: chcheng@mx.nthu.edu.tw
Fax: +886-35724698
Tel: +886-35715131 ext 33381

Abstract

Palladium-catalyzed oxidative carbonylation of 2-arylphenols through C–H bond activation and C–C and C–O bond formation under acid–base free and mild conditions has been developed. The reaction tolerates a variety of substrates and provides biologically important benzopyranone derivatives in up to 87% isolated yield.

Graphical abstract: One pot synthesis of bioactive benzopyranones through palladium-catalyzed C–H activation and CO insertion into 2-arylphenols

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Article information

DOI
https://doi.org/10.1039/C3CC47197G
Article type
Communication
Submitted
20 Sep 2013
Accepted
25 Oct 2013
First published
25 Oct 2013

Chem. Commun., 2013,49, 11797-11799

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One pot synthesis of bioactive benzopyranones through palladium-catalyzed C–H activation and CO insertion into 2-arylphenols

T. Lee, J. Jayakumar, C. Cheng and S. Chuang, Chem. Commun., 2013, 49, 11797 DOI: 10.1039/C3CC47197G

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