Issue 1, 2013
From the journal:

CrystEngComm

Acemetacin polymorphs: a rare case of carboxylic acid catemer and dimer synthons†‡

Palash Sanphui,a   Geetha Bolla,a   Uday Das,b   Alok K. Mukherjee*b  and  Ashwini Nangia*a  

* Corresponding authors

a School of Chemistry, University of Hyderabad, Prof. C. R. Rao Road, , Gachibowli, Central University P.O., Hyderabad 500 046, India

b Department of Physics, Jadavpur University, 188 Raja S. C. Mullick Road, Kolkata 700 032, India
E-mail: akm_ju@rediffmail.com, ashwini.nangia@gmail.com

Abstract

Acemetacin is the first example of an API polymorph with a carboxylic acid catemer and dimer O–H⋯O synthons. The auxiliary stabilization to the catemer motif from stronger C–H⋯O and C–Cl⋯O interactions compared to those in the dimer structure is discussed for a polymorph pair. The crystal structure of the stable dimer polymorph was solved by structure determination from powder X-ray diffraction data (SDPD).

Graphical abstract: Acemetacin polymorphs: a rare case of carboxylic acid catemer and dimer synthons

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Article information

DOI
https://doi.org/10.1039/C2CE26534F
Article type
Communication
Submitted
20 Sep 2012
Accepted
19 Oct 2012
First published
22 Oct 2012

CrystEngComm, 2013,15, 34-38

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Acemetacin polymorphs: a rare case of carboxylic acid catemer and dimer synthons

P. Sanphui, G. Bolla, U. Das, A. K. Mukherjee and A. Nangia, CrystEngComm, 2013, 15, 34 DOI: 10.1039/C2CE26534F

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