Issue 15, 2013
From the journal:

CrystEngComm

Hollow magnetic hydroxyapatite microspheres with hierarchically mesoporous microstructure for pH-responsive drug delivery†

Kaili Lin,*a   Lei Chen,a   Peiyi Liu,b   Zhaoyong Zou,a   Meili Zhang,a   Yuhui Shen,b   Yuqin Qiao,a   Xuanyong Liua  and  Jiang Chang*a  

* Corresponding authors

a State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, P. R. China
E-mail: lklsic@mail.sic.ac.cn, jchang@mail.sic.ac.cn
Fax: +86 21 52413903
Tel: +86 21 52412810

b Department of Orthopaedics, Shanghai Institute of Orthopaedics & Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, China

Abstract

The hollow magnetic hydroxyapatite [Ca10(PO4)6(OH)2, HAp] microspheres with hierarchically mesoporous structures were hydrothermally fabricated using the similar structured CaCO3/Fe3O4 hollow microspheres as the sacrificial hard-templates. The magnetic property, in vitro biocompatibility, drug loading and release properties in different pH solutions were further investigated. The results showed that the magnetic properties for these biocompatible HAp microspheres could be well adjusted by modulation of the Fe3O4 amount, and the drug release rate increased apparently with the decrease of the pH values of the solution medium. The high drug-loading capacity and sustained drug release property suggest that the fabricated multifunctional hollow microspheres have great potential for magnetic and pH responsive drug-delivery applications.

Graphical abstract: Hollow magnetic hydroxyapatite microspheres with hierarchically mesoporous microstructure for pH-responsive drug delivery

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Article information

DOI
https://doi.org/10.1039/C3CE26683D
Article type
Paper
Submitted
15 Oct 2012
Accepted
11 Feb 2013
First published
11 Feb 2013

CrystEngComm, 2013,15, 2999-3008

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Hollow magnetic hydroxyapatite microspheres with hierarchically mesoporous microstructure for pH-responsive drug delivery

K. Lin, L. Chen, P. Liu, Z. Zou, M. Zhang, Y. Shen, Y. Qiao, X. Liu and J. Chang, CrystEngComm, 2013, 15, 2999 DOI: 10.1039/C3CE26683D

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