Issue 15, 2013

Recent developments and future directions in SERS for bioanalysis

Abstract

The ability to develop new and sensitive methods of biomolecule detection is crucial to the advancement of pre-clinical disease diagnosis and effective patient specific treatment. Surface enhanced Raman scattering (SERS) is an optical spectroscopy amenable to this goal, as it is capable of extremely sensitive biomolecule detection and multiplexed analysis. This perspective highlights where SERS has been successfully used to detect target biomolecules, specifically DNA and proteins, and where in vivo analysis has been successfully utilised. The future of SERS development is discussed and emphasis is placed on the steps required to transport this novel technique from the research laboratory to a clinical setting for medical diagnostics.

Graphical abstract: Recent developments and future directions in SERS for bioanalysis

Article information

Article type
Perspective
Submitted
31 Oct 2012
Accepted
11 Dec 2012
First published
15 Jan 2013

Phys. Chem. Chem. Phys., 2013,15, 5312-5328

Recent developments and future directions in SERS for bioanalysis

M. M. Harper, K. S. McKeating and K. Faulds, Phys. Chem. Chem. Phys., 2013, 15, 5312 DOI: 10.1039/C2CP43859C

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