Issue 19, 2013
From the journal:

Dalton Transactions

Non-classical anticancer agents: on the way to water soluble zinc(ii) heteroleptic complexes†

Barbara Sanz Mendiguchia,a   Daniela Pucci,*a   Teresa F. Mastropietro,a   Mauro Ghedinia  and  Alessandra Crispini*b  

* Corresponding authors

a Centro di Eccellenza CEMIF.CAL, LASCAMM CR-INSTM and Laboratorio Regionale Licryl, CNR-INFM, Dipartimento di Chimica, Università della Calabria, 87030 Arcavacata di Rende (CS), Italy
E-mail: d.pucci@unical.it

b Centro di Eccellenza CEMIF.CAL-LASCAMM, CR-INSTM, Dipartimento di Chimica, Dipartimento di Scienze Farmaceutiche, Università della Calabria, Italy
E-mail: a.crispini@unical.it

Abstract

Two new heteroleptic Zn(II) complexes of the 4,4′-bis(hydroxymethyl)-2,2′-bipyridine have been synthesized by using different stoichiometric ratios of tropolone. In an attempt to induce the formation of metal complex co-crystals, liquid assisted solid state reaction followed by solvent crystallization has been conducted by using the new Zn(II) tropolonate derivatives 1 and 2 with saccharin. The novel Zn(II) species obtained exhibits different structures and properties with respect to their precursors, due to a hydrogen exchange between saccharin and the tropolonate coordinated ligand.

Graphical abstract: Non-classical anticancer agents: on the way to water soluble zinc(ii) heteroleptic complexes

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Article information

DOI
https://doi.org/10.1039/C3DT50367D
Article type
Paper
Submitted
06 Feb 2013
Accepted
18 Feb 2013
First published
18 Feb 2013

Dalton Trans., 2013,42, 6768-6774

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Non-classical anticancer agents: on the way to water soluble zinc(II) heteroleptic complexes

B. S. Mendiguchia, D. Pucci, T. F. Mastropietro, M. Ghedini and A. Crispini, Dalton Trans., 2013, 42, 6768 DOI: 10.1039/C3DT50367D

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