Bifunctional polypyridyl-Ru(II) complex grafted onto gadolinium-based nanoparticles for MR-imaging and photodynamic therapy

Charles Truillet; Francois Lux; Juliette Moreau; Mickaël Four; Lucie Sancey; Sylviane Chevreux; Gaëlle Boeuf; Pascal Perriat; Céline Frochot; Rodolphe Antoine; Philippe Dugourd; Christophe Portefaix; Christine Hoeffel; Muriel Barberi-Heyob; Christine Terryn; Laurence van Gulick; Gilles Lemercier; Olivier Tillement

doi:10.1039/C3DT50946J

Bifunctional polypyridyl-Ru(ii) complex grafted onto gadolinium-based nanoparticles for MR-imaging and photodynamic therapy†

Charles Truillet,^a Francois Lux,*^a Juliette Moreau,^b Mickaël Four,^b Lucie Sancey,^a Sylviane Chevreux,^b Gaëlle Boeuf,^b Pascal Perriat,^c Céline Frochot,^dj Rodolphe Antoine,^e Philippe Dugourd,^e Christophe Portefaix,^f Christine Hoeffel,^f Muriel Barberi-Heyob,^gj Christine Terryn,^h Laurence van Gulick,ⁱ Gilles Lemercier*^bj and Olivier Tillement^a

Author affiliations

* Corresponding authors

^a Institut Lumière-Matière – Université de Lyon, Équipe Fennec UMR CNRS n°, 5306 – 69622 Villeurbanne, France
E-mail: francois.lux@univ-lyon1.fr

^b Université de Reims Champagne-Ardenne, ICMR UMR CNRS n° 7312, BP 1039 – 51687, Reims Cedex 2, France
E-mail: gilles.lemercier@univ-reims.fr

^c Matériaux Ingénierie et Science, INSA-Lyon, UMR 5510 CNRS, Université de Lyon, 69621 Villeurbanne Cedex, France

^d Laboratoire Réactions et Génie des Procédés UMR 7274 CNRS, Université de Lorraine, 1, rue Grandville – 54000, Nancy, France

^e Institut Lumière Matière, UMR5306 Université Lyon 1-CNRS, Université de Lyon, 69622 Villeurbanne cedex, France

^f Service de Radiologie, CHU de Reims-H, - 51092 Reims Cedex, France

^g CRAN UMR 7039 CNRS, Université de Lorraine, Département Santé-Biologie-Signal, Vandoeuvre-les-Nancy, France

^h Plate-forme IBISA, SFR CAP-SANTE, Université de Reims Champagne Ardenne, Reims, France

ⁱ Laboratoire Matrice Extracellulaire et Dynamique Cellulaire (MEDyC) – FRE CNRS 3481, Champagne Ardenne, Reims, France

^j GDR CNRS n° 3049 “Médicaments Photoactivables Photochimiothérapie” (Photomed), ,

Abstract

The synthesis, optical properties and efficiency of new multifunctional nanoparticles as theranostic (fluorescence/MRI/PDT) agents are described. They are based on a polysiloxane network and surrounded by gadolinium(III) chelates and ruthenium(II) complexes. The size of the nanoparticles is maintained under 5 nm in order to permit their efficient elimination from the body. Their potential use as a theranostic agent (PDT/MRI) is described. The magnetic properties of the nanoparticles are studied by relaxometry (r₁ = 9.21 mM⁻¹ s⁻¹ at 40 MHz; r₂/r₁ = 1.14) and the signal enhancement is validated by the acquisition of phantoms on a 3 T MRI imager. The therapeutic potential for photodynamic therapy of the nanoparticles has been studied in vitro on HEK293 cells and an effective quantum yield of 0.33 for ¹O₂ production has been determined in deuterated water.

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Bifunctional polypyridyl-Ru(ii) complex grafted onto gadolinium-based nanoparticles for MR-imaging and photodynamic therapy†

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Bifunctional polypyridyl-Ru(II) complex grafted onto gadolinium-based nanoparticles for MR-imaging and photodynamic therapy

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