Issue 3, 2013

CuSO4-catalyzed three-component reaction of α-diazo ester, water and isatin: an efficient approach to oxindole derivatives

Abstract

A highly efficient three-component reaction of α-diazo ester, water and isatin was developed by using CuSO4 as the catalyst. In this reaction, water was used as both a reactant and the solvent. With this highly environmentally benign and economical protocol, a series of 3-hydroxyindolin-2-one derivatives were efficiently produced in good yields with moderate to high diastereoselectivities.

Graphical abstract: CuSO4-catalyzed three-component reaction of α-diazo ester, water and isatin: an efficient approach to oxindole derivatives

Supplementary files

Article information

Article type
Communication
Submitted
29 Oct 2012
Accepted
16 Dec 2012
First published
17 Dec 2012

Green Chem., 2013,15, 620-624

CuSO4-catalyzed three-component reaction of α-diazo ester, water and isatin: an efficient approach to oxindole derivatives

C. Jing, T. Shi, D. Xing, X. Guo and W. Hu, Green Chem., 2013, 15, 620 DOI: 10.1039/C2GC36708D

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