Issue 2, 2013
From the journal:

Lab on a Chip

Microfluidic assisted self-assembly of chitosan based nanoparticles as drug delivery agents†

Fatemeh Sadat Majedi,ab   Mohammad Mahdi Hasani-Sadrabadi,*ab   Shahriar Hojjati Emami,b   Mohammad Ali Shokrgozar,c   Jules John VanDersarl,a   Erfan Dashtimoghadam,b   Arnaud Bertscha  and  Philippe Renaud*a  

* Corresponding authors

a Laboratoire de Microsystemes (LMIS4), École Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne, Switzerland
E-mail: mahdi.hasani@gmail.com, philippe.renaud@epfl.ch
Tel: +41 21 69 3259600.

b Departments of Biomedical Engineering and Polymer Engineering, Amirkabir University of Technology, Tehran, Iran

c National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran

Abstract

We present a microfluidic platform for the synthesis of monodisperse chitosan based nanoparticles via self-assembly at physiological pH. The resultant nanoparticles are shown to encapsulate hydrophobic anticancer drugs while providing a sustainable release profile with high tunability.

Graphical abstract: Microfluidic assisted self-assembly of chitosan based nanoparticles as drug delivery agents

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Article information

DOI
https://doi.org/10.1039/C2LC41045A
Article type
Communication
Submitted
14 Sep 2012
Accepted
05 Nov 2012
First published
07 Nov 2012

Lab Chip, 2013,13, 204-207

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Microfluidic assisted self-assembly of chitosan based nanoparticles as drug delivery agents

F. S. Majedi, M. M. Hasani-Sadrabadi, S. Hojjati Emami, M. A. Shokrgozar, J. J. VanDersarl, E. Dashtimoghadam, A. Bertsch and P. Renaud, Lab Chip, 2013, 13, 204 DOI: 10.1039/C2LC41045A

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