Issue 5, 2013
From the journal:

Nanoscale

Virus-mimicking nano-constructs as a contrast agent for near infrared photoacoustic imaging†‡

Sharad Gupta,§a   Muhammad R. Chatni,§b   Ayala L. N. Rao,c   Valentine I. Vullev,a   Lihong V. Wang*b  and  Bahman Anvari*a  

* Corresponding authors

a Department of Bioengineering, University of California, Riverside, Riverside, CA 92521, USA
E-mail: anvarib@ucr.edu

b Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 963130, USA
E-mail: lhwang@seas.wustl.edu

c Department of Plant Pathology and Microbiology, University of California, Riverside, Riverside, CA 92521, USA

Abstract

We report the first proof-of-principle demonstration of photoacoustic imaging using a contrast agent composed of a plant virus protein shell, which encapsulates indocyanine green (ICG), the only FDA-approved near infrared chromophore. These nano-constructs can provide higher photoacoustic signals than blood in tissue phantoms, and display superior photostability compared to non-encapsulated ICG. Our preliminary results suggest that the constructs do not elicit an acute immunogenic response in healthy mice.

Graphical abstract: Virus-mimicking nano-constructs as a contrast agent for near infrared photoacoustic imaging

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Article information

DOI
https://doi.org/10.1039/C3NR34124K
Article type
Communication
Submitted
16 Dec 2012
Accepted
04 Jan 2013
First published
08 Jan 2013

Nanoscale, 2013,5, 1772-1776

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Virus-mimicking nano-constructs as a contrast agent for near infrared photoacoustic imaging

S. Gupta, M. R. Chatni, A. L. N. Rao, V. I. Vullev, L. V. Wang and B. Anvari, Nanoscale, 2013, 5, 1772 DOI: 10.1039/C3NR34124K

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