The first ratiometric fluorescent probes for aminopeptidase N cell imaging

Laizhong Chen; Wei Sun; Jing Li; Zhenzhen Liu; Zhao Ma; Wei Zhang; Lupei Du; Wenfang Xu; Hao Fang; Minyong Li

doi:10.1039/C2OB26564H

The first ratiometric fluorescent probes for aminopeptidase N cell imaging†‡

Laizhong Chen,^a Wei Sun,^a Jing Li,^a Zhenzhen Liu,^a Zhao Ma,^a Wei Zhang,^a Lupei Du,^a Wenfang Xu,^a Hao Fang^a and Minyong Li*^a

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^a Department of Medicinal Chemistry, Key Laboratory of Chemical Biology of Natural Products (MOE), School of Pharmacy, Shandong University, Jinan, Shandong 250012, China
E-mail: mli@sdu.edu.cn
Tel: +86-531-8838-2076

Abstract

In the current paper, three activity-based colorimetric and ratiometric fluorescent probes based on a naphthalimide fluorophore were well designed and synthesized, which can be recognized and hydrolyzed by aminopeptidase N (APN) at both the enzymatic and cellular level by following the fluorescent emission wavelength change from blue to green light. As a result, these molecules were successfully identified as the first ratiometric fluorescent probes for APN cell imaging.

Organic & Biomolecular Chemistry

The first ratiometric fluorescent probes for aminopeptidase N cell imaging†‡

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The first ratiometric fluorescent probes for aminopeptidase N cell imaging

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