Synthesis of sterically encumbered C10-arylated benzo[h]quinolines using ortho-substituted aryl boronic acids†
Abstract
The challenging coupling of 10-halobenzo[h]quinolines with ortho-substituted aryl boronic acids has been achieved using Pd(OAc)2/P(O)Ph3 as the catalytic system. High yields were obtained for diversely functionalised substrates under mild reaction conditions.