Issue 3, 2013
From the journal:

Organic & Biomolecular Chemistry

Integrin and matrix metalloprotease dual-targeting with an MMP substrate–RGD conjugate†

Christiane H. F. Wenk,abc   Véronique Josserand,bc   Pascal Dumy,ac   Jean-Luc Coll*bc  and  Didier Boturyn*ac  

* Corresponding authors

a Département de Chimie Moléculaire, CNRS: UMR 5250, ICMG FR 2607, Grenoble cedex 9, France
E-mail: didier.boturyn@ujf-grenoble.fr

b INSERM U823, Grenoble, France
E-mail: jean-luc.coll@ujf-grenoble.fr
Fax: +33 4 7654 9413
Tel: +33 4 7654 9553

c Université Joseph Fourier – Grenoble I, 570, rue de la chimie, BP53, 38041 Grenoble cedex 9, France
Fax: +33 4 5652 0803
Tel: +33 4 5652 0832

Abstract

A fluorescent clustered RGD-containing ligand encompassing an MMP substrate was designed and successfully used in vivo for the dual-targeting of αVβ3 integrin receptors and MMP-9 extracellular proteases in the tumor region.

Graphical abstract: Integrin and matrix metalloprotease dual-targeting with an MMP substrate–RGD conjugate

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Article information

DOI
https://doi.org/10.1039/C2OB26926K
Article type
Paper
Submitted
01 Oct 2012
Accepted
14 Nov 2012
First published
14 Nov 2012

Org. Biomol. Chem., 2013,11, 448-452

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Integrin and matrix metalloprotease dual-targeting with an MMP substrate–RGD conjugate

C. H. F. Wenk, V. Josserand, P. Dumy, J. Coll and D. Boturyn, Org. Biomol. Chem., 2013, 11, 448 DOI: 10.1039/C2OB26926K

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