Issue 11, 2013
From the journal:

Organic & Biomolecular Chemistry

Direct use of formamides as amino group sources via C–N bond cleavage: a catalytic oxidative synthesis of α-ketoamides from acetophenones and formamides under metal-free conditions†

Qiong Zhao,a   Tao Miao,a   Xiaobin Zhang,a   Wei Zhoua  and  Lei Wang*ab  

* Corresponding authors

a Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000, P R China
E-mail: leiwang@chnu.edu.cn
Fax: +86-561-309-0518
Tel: +86-561-380-2069

b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P R China

Abstract

An efficient and direct use of formamides as amino group sources for the synthesis of α-ketoamides was developed under metal-free conditions. The reaction was based on the oxidative coupling of acetophenones with formamides and generated the desired products in good yields in the presence of t-BuOOH/I2/PhCO2H.

Graphical abstract: Direct use of formamides as amino group sources via C–N bond cleavage: a catalytic oxidative synthesis of α-ketoamides from acetophenones and formamides under metal-free conditions

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Article information

DOI
https://doi.org/10.1039/C3OB27433K
Article type
Paper
Submitted
16 Dec 2012
Accepted
14 Jan 2013
First published
16 Jan 2013

Org. Biomol. Chem., 2013,11, 1867-1873

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Direct use of formamides as amino group sources via C–N bond cleavage: a catalytic oxidative synthesis of α-ketoamides from acetophenones and formamides under metal-free conditions

Q. Zhao, T. Miao, X. Zhang, W. Zhou and L. Wang, Org. Biomol. Chem., 2013, 11, 1867 DOI: 10.1039/C3OB27433K

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