Issue 18, 2013
From the journal:

Organic & Biomolecular Chemistry

The development of a one pot, regiocontrolled, three-component reaction for the synthesis of thieno[2,3-c]pyrroles†

Cynthia M. Honga  and  Alexander V. Statsyuk*a  

* Corresponding authors

a Department of Chemistry, Center for Molecular Innovation and Drug Discovery, Chemistry of Life Processes Institute, Silverman Hall, Northwestern University, Evanston, IL, USA
E-mail: a-statsyuk@northwestern.edu
Fax: +1 847-491-7713
Tel: +1 847-467-1875

Abstract

A three-component reaction has been developed that allows the regioselective synthesis of thieno[2,3-c]pyrroles. The reaction is based on the ability of 2-acetyl-3-thiophenecarboxaldehyde to react with amine and thiol nucleophiles to produce the corresponding tri-substituted thieno[2,3-c]pyrroles, with water as the only by-product. The developed reaction expands the range of synthetically accessible, tri-substituted thieno[2,3-c]pyrroles.

Graphical abstract: The development of a one pot, regiocontrolled, three-component reaction for the synthesis of thieno[2,3-c]pyrroles

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Article information

DOI
https://doi.org/10.1039/C3OB27492F
Article type
Communication
Submitted
23 Dec 2012
Accepted
19 Mar 2013
First published
19 Mar 2013

Org. Biomol. Chem., 2013,11, 2932-2935

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The development of a one pot, regiocontrolled, three-component reaction for the synthesis of thieno[2,3-c]pyrroles

C. M. Hong and A. V. Statsyuk, Org. Biomol. Chem., 2013, 11, 2932 DOI: 10.1039/C3OB27492F

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