Issue 17, 2013
From the journal:

Organic & Biomolecular Chemistry

Copper-catalyzed aromatic C–H bond halogenation with lithium halides under aerobic conditions†

Song Mo,b   Yamin Zhua  and  Zengming Shen*a  

* Corresponding authors

a School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, China
E-mail: shenzengming@sjtu.edu.cn
Fax: +86-21-54741297

b Department of Chemistry, College of Life and Environment Sciences, Shanghai Normal University, 100 Guilin Road, Shanghai, China

Abstract

A concise and practical Cu-catalyzed protocol for the preparation of chloro- and bromoarenes via C–H bond activation has been developed. The advantages of this strategy are the employment of cheap Cu(NO3)2·3H2O, LiX and O2, and its compatibility with both electron-donating and electron-withdrawing substituents on aryl rings.

Graphical abstract: Copper-catalyzed aromatic C–H bond halogenation with lithium halides under aerobic conditions

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Article information

DOI
https://doi.org/10.1039/C3OB40185E
Article type
Communication
Submitted
28 Jan 2013
Accepted
15 Feb 2013
First published
20 Feb 2013

Org. Biomol. Chem., 2013,11, 2756-2760

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Copper-catalyzed aromatic C–H bond halogenation with lithium halides under aerobic conditions

S. Mo, Y. Zhu and Z. Shen, Org. Biomol. Chem., 2013, 11, 2756 DOI: 10.1039/C3OB40185E

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