Issue 37, 2013

Copper(ii)-catalyzed trifluoromethylation of N-aryl imines

Abstract

Methods for imine trifluoromethylation are of great importance because amines with trifluoromethylated stereogenic centers are useful building blocks for synthetic chemistry and drug discovery. Herein, we describe a new copper(II)-catalyzed imine trifluoromethylation method without the use of Lewis base activators, presumably through cooperative activation.

Graphical abstract: Copper(ii)-catalyzed trifluoromethylation of N-aryl imines

Supplementary files

Article information

Article type
Communication
Submitted
20 Jun 2013
Accepted
24 Jul 2013
First published
24 Jul 2013

Org. Biomol. Chem., 2013,11, 6242-6245

Copper(II)-catalyzed trifluoromethylation of N-aryl imines

Y. Zhang, J. Liu and H. Xu, Org. Biomol. Chem., 2013, 11, 6242 DOI: 10.1039/C3OB41283K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements