Issue 5, 2013
From the journal:

RSC Advances

One-pot synthesis of substituted 2,5-dihydrofurans from β-oxo amides and cinnamaldehydes†

Xu Liu,a   Xin Xin,a   Dexuan Xiang,a   Yongjiu Liang,*a   Xiaoqing Xin,a   Wenliang Lia  and  Dewen Dong*ab  

* Corresponding authors

a Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China
E-mail: dwdong@ciac.jl.cn
Fax: +86 431 85693057
Tel: +86 431 85262190

b Changzhou Institute of Energy Storage Materials & Devices, Changzhou, 213000, P. R. China

Abstract

A facile and efficient one-pot synthesis of substituted 2,5-dihydrofurans from cinnamaldehydes and β-oxo amides is described, and a mechanism involving the intramolecular oxidative cyclization of penta-2,4- dienamides, i.e. Knoevenagel condensation products, forming a new C–O bond in the presence of phenyliodine diacetate (PIDA) is proposed.

Graphical abstract: One-pot synthesis of substituted 2,5-dihydrofurans from β-oxo amides and cinnamaldehydes

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Article information

DOI
https://doi.org/10.1039/C2RA21820H
Article type
Communication
Submitted
15 Aug 2012
Accepted
23 Nov 2012
First published
23 Nov 2012

RSC Adv., 2013,3, 1346-1349

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One-pot synthesis of substituted 2,5-dihydrofurans from β-oxo amides and cinnamaldehydes

X. Liu, X. Xin, D. Xiang, Y. Liang, X. Xin, W. Li and D. Dong, RSC Adv., 2013, 3, 1346 DOI: 10.1039/C2RA21820H

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