Phospholipid micelle encapsulated gadolinium oxide nanoparticles for imaging and gene delivery

Abstract

We encapsulated gadolinium oxide (Gd₂O₃) nanoparticles within phospholipid micelles as a novel low cytotoxic T₁-weighted MRI imaging contrast agent (MGdNPs) that can also deliver small molecules such as DNA plasmids. MGdNPs show relatively good MRI relaxivity values, negligible cytotoxicity, excellent cellular uptake and expression of DNA plasmids in vivo. Biodistribution studies in mice show that intranasal and intraperitoneal administration of MGdNPs can effectively target specific organs.