Issue 33, 2013
From the journal:

RSC Advances

Generation of diverse isoquinoline N-oxides in an aqueous system†

Huanhuan Wang,a   Mengdan Zhu,b   Shengqing Yea  and  Jie Wu*ac  

* Corresponding authors

a Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China
E-mail: jie_wu@fudan.edu.cn
Fax: 86 21 6564 1740
Tel: 86 21 6510 2412

b Jianping Senior High School, 517 Gushan Road, Shanghai 200135, China

c State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China

Abstract

4-Halo isoquinoline N-oxides could be synthesized efficiently via the electrophilic cyclization of 2-alkynylbenzaldoximes, involving the in situ generation of the halonium ion in water. The one-pot cyclization–Suzuki reaction in an aqueous system afforded the functionalized isoquinoline N-oxides in good yields.

Graphical abstract: Generation of diverse isoquinoline N-oxides in an aqueous system

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Article information

DOI
https://doi.org/10.1039/C3RA42730G
Article type
Communication
Submitted
14 Jun 2013
Accepted
26 Jun 2013
First published
26 Jun 2013

RSC Adv., 2013,3, 13626-13629

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Generation of diverse isoquinoline N-oxides in an aqueous system

H. Wang, M. Zhu, S. Ye and J. Wu, RSC Adv., 2013, 3, 13626 DOI: 10.1039/C3RA42730G

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