Issue 39, 2013
From the journal:

RSC Advances

Facile synthesis and newly found biological activity of aminolyzed tung oil components with conjugated double bonds†

Zhiyong Ren,*a   Chunli Zhang,b   Lei Jiang,a   Huafen Wang,a   Wei Zhao,a   Yang Fua  and  Yanbing Zhang*b  

* Corresponding authors

a High & New Technology Research Center of Henan Academy of Sciences, Zhengzhou, P. R. China
E-mail: zyren23@sina.com
Fax: +86 371 65727239
Tel: +86 371 65511787

b School of Pharmaceutical Sciences of Zhengzhou University, Zhengzhou 450001, P. R. China
E-mail: zhangyb@zzu.edu.cn

Abstract

Three novel hydroxylated tung oil (HTO) components with three conjugated double bonds were synthesized by aminolysis of tung oil with diethylolamine, and their cytotoxic effects on five human tumor cell lines were revealed for the first time. Compared with conjugated linolenic acid (CLnA) and conjugated linoleic acid (CLA) which have anti-cancer activity, the carboxyl-free HTO compounds also exhibited a cytotoxic effect against some tumor cell lines.

Graphical abstract: Facile synthesis and newly found biological activity of aminolyzed tung oil components with conjugated double bonds

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Article information

DOI
https://doi.org/10.1039/C3RA42860E
Article type
Communication
Submitted
08 Jun 2013
Accepted
25 Jul 2013
First published
31 Jul 2013

RSC Adv., 2013,3, 17712-17716

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Facile synthesis and newly found biological activity of aminolyzed tung oil components with conjugated double bonds

Z. Ren, C. Zhang, L. Jiang, H. Wang, W. Zhao, Y. Fu and Y. Zhang, RSC Adv., 2013, 3, 17712 DOI: 10.1039/C3RA42860E

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