Rhenium(I) phenanthrolines bearing electron withdrawing CF3 substituents: synthesis, characterization and biological evaluation

Carl Redshaw; Scott Watkins; Simon M. Humphrey; Philip C. Bulman Page; Shane Ashby; Yimin Chao; Christopher J. Herbert; Anja Mueller

doi:10.1039/C3RA43207F

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Rhenium(i) phenanthrolines bearing electron withdrawing CF₃ substituents: synthesis, characterization and biological evaluation†

Carl Redshaw,*^a Scott Watkins,^b Simon M. Humphrey,^c Philip C. Bulman Page,^d Shane Ashby,^d Yimin Chao,^d Christopher J. Herbert^d and Anja Mueller*^e

Author affiliations

* Corresponding authors

^a Department of Chemistry, University of Hull, Cottingham Rd, Hull, UK HU6 7RX
E-mail: c.redshaw@hull.ac.uk

^b CSIRO Materials Science and Engineering, Flexible Electronics Theme, Bayview Avenue, Clayton South, Victoria, Australia

^c Department of Chemistry, The University of Texas at Austin, Welch Hall 2.204, 105 E. 24th St. A5300, Austin, TX 78712-1224, USA

^d School of Chemistry, University of East Anglia, Norwich, UK NR4 7TJ

^e School of Pharmacy, University of East Anglia, Norwich, UK NR4 7TJ
E-mail: anja.mueller@uea.ac.uk

Abstract

Rhenium(I) tricarbonyl complexes bearing a 2,4,7,9-tetraphenylphenanthroline ligand, where the 2,9-phenyl groups have either meta- or para-CF₃ groups, have been screened against a selection of cell lines. The meta derivative shows anticancer activity against HeLa and A549 cell lines, whereas the para derivative causes proliferation of HL-60 cells, whilst showing toxicity towards A549 cells.

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Article information

DOI: https://doi.org/10.1039/C3RA43207F
Article type: Communication
Submitted: 25 Jun 2013
Accepted: 02 Oct 2013
First published: 04 Oct 2013
This article is Open Access

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RSC Adv., 2013,3, 23963-23966

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Rhenium(I) phenanthrolines bearing electron withdrawing CF₃ substituents: synthesis, characterization and biological evaluation

C. Redshaw, S. Watkins, S. M. Humphrey, P. C. Bulman Page, S. Ashby, Y. Chao, C. J. Herbert and A. Mueller, RSC Adv., 2013, 3, 23963 DOI: 10.1039/C3RA43207F

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