Spacer length shapes drug release and therapeutic efficacy of traceless disulfide-linked ADCs targeting the tumor neovasculature†
Abstract
We systematically investigated how the therapeutic efficacy of a traceless, vascular targeting antibody–
* Corresponding authors
a
Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH Zürich), Wolfgang-Pauli Str. 10, 8093 Zürich, Switzerland
E-mail:
Goncalo.Bernardes@pharma.ethz.ch, Goncalo.Bernardes@linacre.oxon.org
Fax: +41 44633 1358
b Philochem AG, Libernstrasse 3, 8112 Otelfingen, Switzerland
c Department of Biochemistry, University of Zürich, Winterthurerstr. 190, 8057 Zürich, Switzerland
d Department of Biology, Institute of Molecular Biology and Biophysics, Swiss Federal Institute of Technology (ETH Zürich), Schafmattstrasse 20, 8093 Zürich, Switzerland
We systematically investigated how the therapeutic efficacy of a traceless, vascular targeting antibody–
M. Steiner, I. Hartmann, E. Perrino, G. Casi, S. Brighton, I. Jelesarov, G. J. L. Bernardes and D. Neri, Chem. Sci., 2013, 4, 297 DOI: 10.1039/C2SC21107F
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