Issue 9, 2013

Simple DNA-based logic gates responding to biomolecules and metal ions

Abstract

The combination of chemical and molecular technologies to emulate silicon-based processing has arisen as a fascinating area of research in the scientific community. This has stimulated the development of molecular-scale logic gates that can parallel the Boolean functions representing the fundamental basis of modern computing. In this regard, the extraordinary diversity of nucleic acid structures and functions can be potentially harnessed to perform logic operations for molecular computers. In this Perspective, we highlight recent advances in the development of simple DNA logic gates devices producing luminescence, colorimetric, electrochemical or electrochemiluminescence signals responding to biomolecules and metal ions for sensory and computing applications.

Graphical abstract: Simple DNA-based logic gates responding to biomolecules and metal ions

Article information

Article type
Perspective
Submitted
06 Apr 2013
Accepted
19 May 2013
First published
20 May 2013

Chem. Sci., 2013,4, 3366-3380

Simple DNA-based logic gates responding to biomolecules and metal ions

D. Ma, H. He, D. S. Chan and C. Leung, Chem. Sci., 2013, 4, 3366 DOI: 10.1039/C3SC50924A

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