Issue 8, 2013

Peptide-based targeting of fluorescent zinc sensors to the plasma membrane of live cells

Abstract

Combining fluorescent zinc sensors with the facile syntheses and biological targeting capabilities of peptides, we created green- and blue-emitting probes that (i) are readily prepared on the solid-phase, (ii) retain the photophysical and zinc-binding properties of the parent sensor, and (iii) can be directed to the extracellular side of plasma membranes in live cells for detection of mobile zinc.

Graphical abstract: Peptide-based targeting of fluorescent zinc sensors to the plasma membrane of live cells

Supplementary files

Additions and corrections

Article information

Article type
Edge Article
Submitted
11 Apr 2013
Accepted
14 May 2013
First published
29 May 2013

Chem. Sci., 2013,4, 3080-3084

Peptide-based targeting of fluorescent zinc sensors to the plasma membrane of live cells

R. J. Radford, W. Chyan and S. J. Lippard, Chem. Sci., 2013, 4, 3080 DOI: 10.1039/C3SC50974E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements