Prediction of suitable catalyst by 1H NMR: asymmetric synthesis of multisubstituted biaryls by chiral phosphoric acid catalyzed asymmetric bromination

Abstract

We describe herein the “¹H NMR-assisted catalyst screening method,” which enables us to find the suitable catalyst easily and predict enantioselectivity with the same accuracy as the computational method. Based on this method, we constructed multisubstituted biaryls that occur frequently in many biologically active compounds, chiral ligands, and organocatalysts, with excellent enantioselectivities via chiral phosphoric acid-catalyzed asymmetric bromination.