Issue 11, 2014
From the journal:

Analyst

Chemical exchange saturation transfer (CEST): an efficient tool for detecting molecular information on proteins' behaviour†

Dario Livio Longo,*ab   Enza Di Gregorio,a   Riccardo Abategiovanni,a   Alberto Ceccon,c   Michael Assfalg,c   Henriette Molinarid  and  Silvio Aimea  

* Corresponding authors

a Department of Molecular Biotechnologies and Health Sciences, University of Torino, 10126 Torino, Italy
E-mail: dario.longo@unito.it

b Institute for Biostructures and Bioimages (CNR), c/o Molecular Biotechnology Center, University of Torino, Via Nizza 52, 10126 Torino, Italy

c Department of Biotechnology, University of Verona, Strada Le Grazie 15, 37134 Verona, Italy

d NMR Laboratory, ISMAC-CNR, Via Bassini 15, 20133 Milano, Italy

Abstract

A versatile method for assessing protein properties via magnetic resonance imaging (MRI) through chemical exchange saturation transfer (CEST) modality is described. The observed CEST signal changes allow monitoring of protein aggregation processes, protein folding/unfolding steps and interaction with lipid membranes.

Graphical abstract: Chemical exchange saturation transfer (CEST): an efficient tool for detecting molecular information on proteins' behaviour

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Article information

DOI
https://doi.org/10.1039/C4AN00346B
Article type
Communication
Submitted
18 Feb 2014
Accepted
13 Mar 2014
First published
13 Mar 2014

Analyst, 2014,139, 2687-2690

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Chemical exchange saturation transfer (CEST): an efficient tool for detecting molecular information on proteins' behaviour

D. L. Longo, E. Di Gregorio, R. Abategiovanni, A. Ceccon, M. Assfalg, H. Molinari and S. Aime, Analyst, 2014, 139, 2687 DOI: 10.1039/C4AN00346B

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