Issue 15, 2014
From the journal:

Analyst

A nanobody-based electrochemiluminescent immunosensor for sensitive detection of human procalcitonin†

Henan Li,‡a   Yanyan Sun,‡b   Jelle Elseviers,d   Serge Muyldermans,ef   Songqin Liu*a  and  Yakun Wan*bc  

* Corresponding authors

a School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, PR China
E-mail: liusq@seu.edu.cn

b The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, Nanjing 210096, PR China
E-mail: ywan@seu.edu.cn

c Jiangsu Nanobody Engineering and Research Center, Nantong 226010, PR China

d Nanobody Service Facility, VIB, Pleinlaan 2, 1050 Brussels, Belgium

e Cellular and Molecular Immunology, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium

f Structural Biology Research Center, VIB, Pleinlaan 2, 1050 Brussels, Belgium

Abstract

The development of a nanobody-based electrochemiluminescent immunosensor for procalcitonin quantification is described. A highly specific and enhanced sensitivity of target detection was achieved by CdTe quantum dot encapsulated silica nanoparticle-assisted signal amplification.

Graphical abstract: A nanobody-based electrochemiluminescent immunosensor for sensitive detection of human procalcitonin

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Supplementary files

Article information

DOI
https://doi.org/10.1039/C4AN00626G
Article type
Communication
Submitted
07 Apr 2014
Accepted
22 May 2014
First published
22 May 2014

Analyst, 2014,139, 3718-3721

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A nanobody-based electrochemiluminescent immunosensor for sensitive detection of human procalcitonin

H. Li, Y. Sun, J. Elseviers, S. Muyldermans, S. Liu and Y. Wan, Analyst, 2014, 139, 3718 DOI: 10.1039/C4AN00626G

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