Issue 84, 2014
From the journal:

Chemical Communications

Enzymatic synthesis of chiral γ-amino acids using ω-transaminase†

Minsu Shon,‡a   Ramachandran Shanmugavel,‡b   Giyoung Shin,a   Sam Mathew,a   Sang-Hyeup Lee*b  and  Hyungdon Yun*c  

* Corresponding authors

a School of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk, South Korea

b Department of Life Chemistry, Catholic University of Daegu, Gyeongbuk 700-443, Korea
E-mail: leeshh@cu.ac.kr

c Department of Bioscience & Biotechnology, Konkuk University, Seoul 143-701, Korea
E-mail: hyungdon@konkuk.ac.kr
Fax: +82-2-450-0686
Tel: +82-2-450-0496

Abstract

In this study, we successfully synthesized enantiomerically pure (R)- and (S)-γ-amino acids (>99% ee) using ω-transaminase (ω-TA) through kinetic resolution and asymmetric synthesis respectively. The present study demonstrates the high potentiality of ω-TA reaction for the production of chiral γ-amino acids.

Graphical abstract: Enzymatic synthesis of chiral γ-amino acids using ω-transaminase

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Article information

DOI
https://doi.org/10.1039/C3CC44864A
Article type
Communication
Submitted
28 Jun 2013
Accepted
22 Aug 2014
First published
27 Aug 2014

Chem. Commun., 2014,50, 12680-12683

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Enzymatic synthesis of chiral γ-amino acids using ω-transaminase

M. Shon, R. Shanmugavel, G. Shin, S. Mathew, S. Lee and H. Yun, Chem. Commun., 2014, 50, 12680 DOI: 10.1039/C3CC44864A

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