Issue 40, 2014
From the journal:

Chemical Communications

Copper-catalyzed free-radical C–H arylation of pyrroles†

Aurélien Honraedt,a   Marie-Audrey Raux,a   Erwan Le Grognec,a   Denis Jacqueminab  and  François-Xavier Felpin*ab  

* Corresponding authors

a Université de Nantes, UFR Sciences et Techniques, UMR CNRS 6230, CEISAM, 2 rue de la Houssinière, 44322 Nantes Cedex 3, France
E-mail: fx.felpin@univ-nantes.fr
Fax: +33 251 125 40

b Institut Universitaire de France, 103, Boulevard Saint-Michel, 75005 Paris Cedex 05, France

Abstract

A room temperature copper-catalyzed radical arylation of pyrroles with anilines, through in situ generated aryl diazonium salts, has been developed under neutral conditions. Experimental and theoretical studies explain the crucial role of CaCO3 and the high regioselectivity observed.

Graphical abstract: Copper-catalyzed free-radical C–H arylation of pyrroles

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Article information

DOI
https://doi.org/10.1039/C3CC45240A
Article type
Communication
Submitted
11 Jul 2013
Accepted
05 Aug 2013
First published
07 Aug 2013

Chem. Commun., 2014,50, 5236-5238

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Copper-catalyzed free-radical C–H arylation of pyrroles

A. Honraedt, M. Raux, E. L. Grognec, D. Jacquemin and F. Felpin, Chem. Commun., 2014, 50, 5236 DOI: 10.1039/C3CC45240A

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